Binding Measurements
Binding measurement services
We offer rapid expression and KD measurements for antibodies and antibody fragments starting from digital sequences. Our system is capable of producing minibinders, Darpins, VH/VHH/Nanobody binders, HCAbs and IgGs.
Binding Measurements (price includes binder synthesis from digital sequences)
| Service Type | Price/46 Samples | Format |
|
Ranked binding (“Silver”) Crude Cell-Free 1 analyte concentration per sample Low, medium, high ranking Kinetic estimate (ka, kd, KD) |
$5,400 USD + cost of antigen (1 antigen per 46 binders) |
46 samples at a time |
|
KD Measurements from Crude Reactions (“Gold”) Crude Cell-Free 5 analyte concentrations per sample Kinetic analysis (ka, kd, KD) |
$6,700 USD + cost of antigen (1 antigen per 46 binders) |
46 samples at a time |
|
KD Measurements from Purified Constructs (“Platinum”) His-tag purified binders 5 analyte concentrations per sample Kinetic analysis (ka, kd, KD) |
$7,600 USD + cost of antigen (1 antigen per 46 binders) |
46 samples at a time |
These are all done with single-cycle kinetics. Multi-cycle kinetics are available upon request. Pricing is for minibinders, Darpins and VH/VHH/Nanobody binders. Larger binders would be slightly more expensive due to DNA costs.
Additional Information
Measurements are carried out using Nicoya's Alto Digital SPR system.
Timeline is ~3-4 weeks starting with digital sequences.
Note: Binding measurement services are data package only. We do not deliver the purified products.